CALL FOR PAPERS Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle
نویسندگان
چکیده
Adrian R. West, Nishat Zaman, Darren J. Cole, Matthew J. Walker, Wesley R. Legant, Thomas Boudou, Christopher S. Chen, John T. Favreau, Glenn R. Gaudette, Elizabeth A. Cowley, and Geoffrey N. Maksym School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts; and Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada
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CALL FOR PAPERS Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics Matrix stiffness-modulated proliferation and secretory function of the airway smooth muscle cells
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Airway smooth muscle (ASM) cellular and molecular biology is typically studied with single-cell cultures grown on flat 2D substrates. However, cells in vivo exist as part of complex 3D structures, and it is well established in other cell types that altering substrate geometry exerts potent effects on phenotype and function. These factors may be especially relevant to asthma, a disease character...
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